Research
The Lee lab focuses on regenerative medicine
such as stem cells, cancer and vascular biology
Our long-term goal is to establish a Precision Hematopoiesis platform capable of predicting and controlling hematopoietic cell behavior from protein structure and niche remodeling to blood cell production.
Our laboratory seeks to understand and engineer hematopoiesis across molecular, cellular, and microenvironmental scales.
We integrate hematopoietic stem cell and niche biology, cell engineering, and single-cell/spatial multi-omics to uncover the mechanisms governing hematopoietic stem cell homeostasis, mobilization, and lineage differentiation.
By combining AI-based protein structure analysis with functional genomics and cell-state modeling, we aim to move beyond descriptive hematology toward predictive and engineering-based approaches to hematopoiesis.
Our goals are to define stem cell regulation and disease and
how we can utilize information to develop novel therapies.
Especially, we are aiming for characterization of functions of
novel genes in hematological malignancy and solid cancers.
Our research is aimed at identifying targets which can be used
as clinical advances.
We will put expertise and insights into biomedical research to answer biologically important and meaningful questions.